Reply to comment on: Short pulse width widens the therapeutic window of subthalamic neurostimulation
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Reply to comment on: Short pulse width widens the therapeutic window of subthalamic neurostimulation
We have read with interest the comment of McDermott et al. on our article “Short pulse width widens the therapeutic window of subthalamic neurostimulation”. While the authors provide an elegant and sophisticated argument trying to prove our data wrong, they disregard a simple rule of experimentation from the viewpoint of theoretical biophysics: Deep brain stimulation systems do not have a “char...
متن کاملShort pulse width widens the therapeutic window of subthalamic neurostimulation
We explored the impact of pulse durations <60 μsec on the therapeutic window of subthalamic neurostimulation in Parkinson's disease. Current thresholds for full rigidity control and first muscle contractions were evaluated at pulse durations between 20 and 120 μsec during a monopolar review session in four patients. The average therapeutic window was 2.16 mA at 60 μsec, which proportionally inc...
متن کاملComment on: Short pulse width widens the therapeutic window of subthalamic neurostimulation
We wish to comment on the assertion that a “short pulse width widens the therapeutic window of subthalamic neurostimulation,” as reported by Reich et al. In that publication, the authors defined “therapeutic window” in deep brain stimulation as the difference in current between the onset of full rigidity control and the onset of adverse muscle contractions at a given pulse duration. They determ...
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In the comment [1], Zanardi and Rasetti argue that several claims in our recent letter [2] are questionable. Here we show these claims remain true. Our points are that (i) the Hamiltonian (1) in Ref. [2] describes amplitude damping as well as phase damping; (ii) the free-Hamiltonian-elimination (FHE) has feasible implementation in practice and there exists a simple FHE procedure which is design...
متن کاملReply to the Comment
In their comment to the paper “Theory of the evaporation/condensation transition of equilibrium droplets in finite volumes” [Physica A319, 99 (2003)], Biskup et al. claim that in finite systems at fixed density “the physical significance of the conjugate thermodynamic variable is of dubious value”. This claim is critically discussed.
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ژورنال
عنوان ژورنال: Annals of Clinical and Translational Neurology
سال: 2015
ISSN: 2328-9503,2328-9503
DOI: 10.1002/acn3.252